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Yogita Singh ¹, Arun Kumar Jaiswal ¹

Affiliations
1 Neuropharmacology Laboratory, Department of Pharmacology, Institute of Medical Sciences, Banaras Hindu University, Varanasi 221 005, Uttar Pradesh, IN

Abstract

Behavioural teratological effects of prenatal fluoxetine exposure were investigated on behavioural despair and learned helplessness parameters of depression in rats. Pregnant rats were administered fluoxetine (5 and 10 mg/kg/day) orally once a day during the gestation days 13 to 20. The pups born were subjected to forced swimming test of behavioural despair and learned helplessness test at 8 weeks of age. The results indicated that prenatal fluoxetine treatment (5 and 10 mg/kg/day) induced significant increase in time of immobility in forced swimming test and number of escape failures in learned helplessness test in rat offspring. Rat offspring treated with 5 and 10 mg/kg fluoxetine during the prenatal period displayed dose dependent significant increase in time of immobility in behavioural despair test and number of escape failures in learned helplessness test in comparison to control rat offspring. The findings highlight that prenatal fluoxetine treatment caused depressive like behavioural alterations in the rat offspring.

Keywords

Fluoxetine, Behavioural Despair, Learned Helplessness, Prenatal, Rat.

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Yogita Singh ¹, Manju Pandey ¹

Affiliations
1 Department of Psychology, HNBGU, Srinagar, Garhwal, Uttarakhand, IN

Abstract

The present study was carried out with the objective of studying the level of psychic immunity among male and female adolescents. The sample consisted of 80 undergraduate students selected by quota sampling technique on the basis of gender and age. The scale employed for data collection was Psychic Immunity Scale (Self Constructed), 't-test' was computed to analyse the data and to guide the study. The results reveal a significant difference between the psychic immunity of male and female adolescents. The findings indicate that the female adolescents have significantly high psychic immunity than the male adolescents.

Keywords

Adolescents, Female, Male, Psychic Immunity.

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